Fixed drug eruption: about 13 cases

To discuss, through a retrospective study, the epidemiological and clinical aspects and the causative agents of fixed drug eruption. Thirteen cases were collected retrospectively during 11 years. There were 10 females and 3 males with a mean age of 44 years. The lesions correspond to erythematous plaques which fade to leave slate-brown macules in all cases. The most frequent localizations were limbs [12 cases], trunk [6 cases], face [3 cases] and external genitals [3 cases]. Sulfonamides were the most frequent responsible drugs in our series [7 cases]. Fixed drug eruption is characterized by one or more erythematous plaques which recur in the same places after challenge. Sulfonamides are actually the most frequent causative drugs in the different series

[Drug tendon disorders]

Tendinitis is a rare adverse reaction described after drugs use. It's described with drug belonging to the same class. Physiopathology is still unknown. Fluoroquinolones especially pefloxacine, were the most incriminated. This drug induced tendinitis in older people aged more than 60 years. Approximatively one case out of five leads to tendon breaking off. The others lead to a favourable outcome after drug withdrawal. In three cases, tendinitis was described with statines, and concerned 2 men and I woman, aged more than 50 years. Simvastatine was suspected in two cases and the outcome was favourable in all cases after drug withdrawal. Other drugs, like corticosteroids, can exceptionally induce this side effect that can be serious. Consequences of drug tendinitis can then be dangerous and prescription of this class, and especially fluoroquinolones, must be cautious